[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester

Name	Givinostat
Synonyms	CS-2025 Givinostat Gavinostat Givinostat(ITF-2357) Givinostat(free base) [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate [4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester Carbamic acid, N-[4-[(hydroxyamino)carbonyl]phenyl]-, [6-[(diethylamino)methyl]-2-naphthalenyl]methylester
CAS	497833-27-9

Molecular Formula	C24H27N3O4
Molar Mass	421.49
Density	1.259
pKa	8.97±0.10(Predicted)
Storage Condition	2-8℃
Use	Givinostat (ITF-2357) is an HDAC inhibitor. Inhibition of HDAC1 and HDAC3 with an IC50 of 198 nM and 157 nM, respectively.

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